Robert Griffin III began his NFL career by connecting on 19 of 26 passes for 320 yards and two touchdowns, and the Washington Redskins handed the Saints a 40-32 loss in their first game since the bounty scandal that overshadowed New Orleans’ offseason.

Griffin completed his first eight passes, including an 88-yard touchdown pass to Pierre Garcon, tying for the second-longest scoring pass by a quarterback making his NFL debut.

Drew Brees uncharacteristically struggled with accuracy, completing only 46 percent of his throws with two interceptions. But his 339 yards passing and three TDs kept the Saints in the game until his last desperate pass was picked off by Reed Doughty near the Redskins’ goal line.

Bears 41, Colts 21: Jay Cutler threw for 333 yards and two touchdowns and Michael Bush added a pair of scoring runs to spoil quarterback Andrew Luck’s debut.

Brandon Marshall had nine catches for 119 yards and a touchdown in his first game since being reunited with Cutler, and Matt Forte ran for 80 yards and a score.

Luck finished his first NFL game 23 of 45 for 309 yards with a 4-yard touchdown pass to Donnie Avery early in the fourth quarter. He also was intercepted three times.

Eagles 17, Browns 16: Michael Vick overcame four interceptions by throwing a 4-yard touchdown pass to Clay Harbor with 1:18 left in the nerve-racking win.

Vick led the Eagles on a 91-yard scoring drive, capping it with his short toss to Harbor on his career-high 56th pass. Before Vick rallied his team, he played poorly and showed rustiness after playing just 12 snaps during preseason because of injuries.

Vick went 29 of 56 for 317 yards and two TDs.

Browns rookie quarterback Brandon Weeden threw four interceptions, the last to Kurt Coleman with 1:05 remaining.

Vikings 26, Jaguars 23, OT: Rookie Blair Walsh kicked four field goals, including a 55-yarder as regulation time expired and another one in overtime, and Adrian Peterson returned from a left knee injury to lift the Vikings.

Peterson ran 17 times for 84 yards and two touchdowns for the Vikings, who led for most of the second half until Blaine Gabbert’s 39-yard touchdown heave with 20 seconds left in the fourth quarter put the Jaguars back in front.

Lions 27, Rams 23: Matthew Stafford threw a 5-yard touchdown pass to Kevin Smith with 10 seconds left.

Stafford made up for a shaky game by leading an 80-yard, nine-play, game-winning possession that included three passes of at least 18 yards.

Sam Bradford directed a go-ahead drive that set up Greg Zuerlein’s 46-yard field goal and put the Rams ahead 23-20 with 1:55 left. But coach Jeff Fisher’s debut ended with a loss because the Rams could not shut down Stafford in the end.

Stafford had three interceptions before halftime for the first time in his four seasons. Cortland Finnegan had a 31-yard interception return for a TD that gave the Rams a 13-7 lead late in the first half.

Texans 30, Dolphins 10: Arian Foster had two touchdown runs, Matt Schaub threw a TD pass to Andre Johnson, and Houston’s defense dominated rookie Ryan Tannehill and Miami.

Tannehill threw three interceptions in a 6-minute stretch late in the first half.

Schaub threw for 266 yards in his first action since fracturing his right foot in Week 10 last year, and Johnson finished with 119 yards receiving. Texans defensive end J.J. Watt deflected two passes that resulted in interceptions and also had 1½ sacks.

49ers 30, Packers 22: San Francisco’s defense smothered Aaron Rodgers and the Green Bay offense for most of the game, then made one last stand to stop a late rally as the 49ers beat the Packers.

Randall Cobb got the Packers close with a 75-yard punt return for a touchdown, and a 2-point conversion cut the lead to 8. But Rodgers threw an interception to linebacker NaVorro Bowman and Frank Gore ran for a 23-yard touchdown.

Buccaneers 16, Panthers 10: Tampa Bay’s rejuvenated defense came up with two interceptions against Cam Newton and the Buccaneers won their debut under coach Greg Schiano.

Josh Freeman threw a 6-yard touchdown pass to Mike Williams and Connor Barth kicked three field goals to help the Bucs stop a 10-game losing streak.

Newton threw for 303 yards and one touchdown. But the Panthers were shut out in the first half, and the interceptions he threw thwarted Carolina’s chances of overcoming the slow start.